Multimodal Treatment of Chronic Pain

Med Clin North Am. 2016 Jan;100(1):55-64. doi: 10.1016/j.mcna.2015.08.012. Epub 2015 Oct 17.


Most patients with chronic pain receive multimodal treatment. There is scant literature to guide us, but when approaching combination pharmacotherapy, the practitioner and patient must weigh the benefits with the side effects; many medications have modest effect yet carry significant side effects that can be additive. Chronic pain often leads to depression, anxiety, and deconditioning, which are targets for treatment. Structured interdisciplinary programs are beneficial but costly. Interventions have their place in the treatment of chronic pain and should be a part of a multidisciplinary treatment plan. Further research is needed to validate many common combination treatments.

Keywords: Chronic pain treatment; Combination therapy; Interdisciplinary pain treatment; Multidisciplinary chronic pain treatment; Multimodal.

Publication types

  • Review

MeSH terms

  • Analgesia / methods*
  • Chronic Pain / drug therapy
  • Chronic Pain / therapy*
  • Cognitive Behavioral Therapy / methods
  • Combined Modality Therapy / methods*
  • Electric Stimulation Therapy / methods
  • Humans
  • Pain Management / methods*
  • Pain Measurement
  • Psychotherapy / methods
  • Quality of Life
  • Transcranial Magnetic Stimulation / methods