Sinonasal Malignancies of Anterior Skull Base: Histology-driven Treatment Strategies

Otolaryngol Clin North Am. 2016 Feb;49(1):183-200. doi: 10.1016/j.otc.2015.09.012.


The advances in endoscopy have revolutionized the management of sinonasal and skull base lesions. Many complex cancers that traditionally required open approaches are now amenable to purely endoscopic endonasal resection, providing less invasive surgery with lower morbidity but with comparable oncologic outcomes in terms of survival rates. This article discusses the current evidence for the multimodal management of sinonasal and anterior skull base cancers focusing on the different treatment protocols driven by histologic subtypes.

Keywords: Adenocarcinoma; Chemotherapy; Endoscopic endonasal; Mucosal melanoma; Olfactory neuroblastoma; Paranasal sinuses; Radiotherapy; Skull base cancer.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma / surgery
  • Carcinoma / surgery
  • Carcinoma, Adenoid Cystic / surgery
  • Carcinoma, Neuroendocrine / surgery
  • Carcinoma, Squamous Cell / surgery
  • Disease Management
  • Endoscopy / methods*
  • Esthesioneuroblastoma, Olfactory / surgery
  • Hemangiopericytoma / surgery
  • Humans
  • Maxillary Sinus Neoplasms / surgery
  • Nose / surgery*
  • Professional Corporations
  • Skull Base / surgery*
  • Skull Base Neoplasms / mortality
  • Skull Base Neoplasms / surgery*
  • Survival Rate

Supplementary concepts

  • Sinonasal undifferentiated carcinoma