LL-E19085 alpha, a novel antibiotic from Micromonospora citrea: taxonomy, fermentation and biological activity

J Antibiot (Tokyo). 1989 Jun;42(6):846-51. doi: 10.7164/antibiotics.42.846.

Abstract

A new antibacterial antibiotic, designated LL-E19085 alpha, was isolated from the fermentation broth of an actinomycete strain. Based on cultural, physiological, morphological and chemical characteristics, culture LL-E19085 was identified as a new subspecies of Micromonospora citrea. Antibiotic LL-E19085 alpha demonstrated potent activity against a spectrum of Gram-positive aerobic and anaerobic bacteria.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / biosynthesis*
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Bacteria / drug effects*
  • Culture Media
  • Fermentation
  • Mice
  • Micromonospora / classification
  • Micromonospora / growth & development
  • Micromonospora / metabolism*
  • Micromonospora / ultrastructure
  • Microscopy, Electron
  • Molecular Structure
  • Oxazoles / biosynthesis
  • Oxazoles / pharmacology
  • Oxazoles / therapeutic use
  • Spores, Bacterial / ultrastructure
  • Streptococcal Infections / drug therapy*
  • Streptococcus pyogenes / drug effects

Substances

  • Anti-Bacterial Agents
  • Culture Media
  • Oxazoles
  • citreamicin alpha