Biocuration of functional annotation at the European nucleotide archive

Nucleic Acids Res. 2016 Jan 4;44(D1):D58-66. doi: 10.1093/nar/gkv1311. Epub 2015 Nov 28.


The European Nucleotide Archive (ENA; is a repository for the submission, maintenance and presentation of nucleotide sequence data and related sample and experimental information. In this article we report on ENA in 2015 regarding general activity, notable published data sets and major achievements. This is followed by a focus on sustainable biocuration of functional annotation, an area which has particularly felt the pressure of sequencing growth. The importance of functional annotation, how it can be submitted and the shifting role of the biocurator in the context of increasing volumes of data are all discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Data Curation
  • Databases, Nucleic Acid*
  • Molecular Sequence Annotation*
  • Sequence Analysis, DNA*
  • Sequence Analysis, RNA*