The framework of polysaccharide monooxygenase structure and chemistry

Curr Opin Struct Biol. 2015 Dec;35:93-9. doi: 10.1016/ Epub 2015 Nov 23.


Polysaccharide monooxygenases, or PMOs (also known as lytic PMOs or LPMOs), are a group of enzymes discovered in recent years to catalyze the oxidative degradation of carbohydrate polymers. The PMO catalytic domain has a β-sandwich fold that bears a strong resemblance to both immunoglobulin (Ig) and fibronectin type III (FnIII) domains. PMOs are secreted by fungi and bacteria, and there is recent evidence for their roles in pathogenesis, in addition to biomass processing. This review addresses the biological origins and functions of emerging PMO families, as well as describes the aspects of PMO structure that support the chemistry of copper-catalyzed, oxidative polysaccharide degradation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Catalytic Domain
  • Mixed Function Oxygenases / chemistry*
  • Mixed Function Oxygenases / classification
  • Mixed Function Oxygenases / metabolism*
  • Polysaccharides / metabolism*


  • Polysaccharides
  • Mixed Function Oxygenases