Cholinergic hypothesis of depression: a reappraisal

J Clin Psychopharmacol. 1989 Jun;9(3):173-9.


Evidence for the cholinergic hypothesis of depression is reviewed, arguments directed against this hypothesis are set forth, and the strengths and weaknesses of these criticisms are discussed. The authors conclude that the cholinergic hypothesis is tenable but suggest new areas of study.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acetylcholine / physiology
  • Arousal / physiology
  • Brain / physiopathology*
  • Depressive Disorder / physiopathology*
  • Humans
  • Receptors, Cholinergic / physiology*
  • Receptors, Muscarinic / physiology
  • Receptors, Nicotinic / physiology


  • Receptors, Cholinergic
  • Receptors, Muscarinic
  • Receptors, Nicotinic
  • Acetylcholine