A Japanese cross-sectional multicentre study of biomarkers associated with cardiovascular disease in smokers and non-smokers

Biomarkers. 2015;20(6-7):411-21. doi: 10.3109/1354750X.2015.1096303.

Abstract

We performed a cross-sectional, multicentre study in Japan to detect the differences in biomarkers of exposure and cardiovascular biomarkers between smokers and non-smokers. Several clinically relevant cardiovascular biomarkers differed significantly between smokers and non-smokers, including lipid metabolism (high-density lipoprotein cholesterol concentrations - lower in smokers), inflammation (fibrinogen and white blood cell count - both higher in smokers), oxidative stress (8-epi-prostaglandin F2α - higher in smokers) and platelet activation (11-dehydro-thromboxane B2 - higher in smokers) (p ≤ 0.0001). These results provide further evidence showing that cardiovascular biomarkers can discriminate smokers from non-smokers, and could be used to evaluate the risks associated with tobacco products.

Keywords: Biomarkers; Japan; cardiovascular disease; cigarettes; smoking.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Asian People / statistics & numerical data
  • Biomarkers / blood*
  • Biomarkers / urine
  • C-Reactive Protein / metabolism
  • Cardiovascular Diseases / blood*
  • Cardiovascular Diseases / ethnology
  • Cardiovascular Diseases / urine
  • Cholesterol, HDL / blood
  • Cotinine / blood
  • Cotinine / urine
  • Cross-Sectional Studies
  • Dinoprost / analogs & derivatives
  • Dinoprost / blood
  • Female
  • Fibrinogen / metabolism
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Smoking / blood*
  • Smoking / ethnology
  • Smoking / urine
  • Thromboxane B2 / analogs & derivatives
  • Thromboxane B2 / blood

Substances

  • Biomarkers
  • Cholesterol, HDL
  • 8-epi-prostaglandin F2alpha
  • Thromboxane B2
  • 11-dehydro-thromboxane B2
  • Fibrinogen
  • C-Reactive Protein
  • Dinoprost
  • Cotinine