We develop coarse-grained (CG) computer simulation models of poly(3-hexylthiophene) (P3HT) and P3HT/fullerene-C60 mixtures, in which collections of atoms from a physically accurate atomistic model are mapped onto a smaller number of "superatoms". These CG models allow much larger systems to be simulated for longer durations than is achievable atomistically, making it possible to study in molecular detail the morphology of polymer/fullerene bulk heterojunctions at length and time scales relevant to organic photovoltaic devices. We demonstrate that our CG models, parametrized at two state points, accurately capture the structure of atomistic systems at other points in the mixture phase diagram. Finally, we use our CG models to study the dynamic evolution of the microstructure of a P3HT/C60 bulk heterojunction in a system approaching the device scale.