Phospha-fluorescein: a red-emissive fluorescein analogue with high photobleaching resistance

Chem Commun (Camb). 2016 Jan 21;52(6):1120-3. doi: 10.1039/c5cc09345g.


Phospha-fluorescein (POF), a phosphine oxide-containing analogue of fluorescein, was synthesized and its photophysical properties were examined. Compared with fluorescein and sila-fluorescein, POF displayed significantly red-shifted absorption and fluorescence as well as superior photobleaching resistance, while retaining the pH-responsive characteristics of fluorescein dyes.

Publication types

  • Research Support, Non-U.S. Gov't