Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells: a rare case report and review of the literature

Int J Clin Exp Pathol. 2015 Sep 1;8(9):11785-91. eCollection 2015.


Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UCPOGC) is an extremely rare non-endocrine pancreatic tumor. To date, some cases have been reported, however, histogenesis and biologic behavior of UCPOGC remain controversial. We report a case of an UCPOGC in a 54-year-old female, who presented with a three-month history of recurrent abdominal pain without any incentive. Abdominal computed tomography (CT) revealed a large cystic mass of 10.5 × 9.3 cm in the body and tail of the pancreas compressing the adjacent bowel loop and stomach. The preliminary diagnosis was considered as a malignant tumor of body and tail of the pancreas. The patient had open distal pancreatic mass resection with splenectomy and according to the results of histopathological and immunohistochemical studies, the diagnosis of an UCPOGC was established.

Keywords: Osteoclast-like giant cells; pancreas; undifferentiated carcinoma.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers, Tumor / analysis
  • Carcinoma / chemistry
  • Carcinoma / pathology*
  • Carcinoma / surgery
  • Cell Differentiation*
  • Female
  • Giant Cell Tumors / chemistry
  • Giant Cell Tumors / pathology*
  • Giant Cell Tumors / surgery
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Osteoclasts / chemistry
  • Osteoclasts / pathology*
  • Pancreatectomy
  • Pancreatic Neoplasms / chemistry
  • Pancreatic Neoplasms / pathology*
  • Pancreatic Neoplasms / surgery
  • Splenectomy
  • Tomography, X-Ray Computed
  • Tumor Burden


  • Biomarkers, Tumor