Patient Satisfaction and Efficacy of Full-Facial Rejuvenation Using a Combination of Botulinum Toxin Type A and Hyaluronic Acid Filler

Dermatol Surg. 2015 Dec:41 Suppl 1:S325-32. doi: 10.1097/DSS.0000000000000548.


Background: Combination treatments using hyaluronic acid (HA) fillers and botulinum toxin Type A (BoNT-A) are common in aesthetic medicine; however, this has been evaluated in only a few clinical studies.

Objective: To evaluate subject satisfaction, efficacy, and safety of BoNT-A (Speywood Unit; s.U) and a range of HA fillers for full-facial aesthetic rejuvenation.

Materials and methods: A 6-month, multicenter, open-label clinical study, using BoNT-A (s.U) and 5 HA fillers to treat up to 13 facial zones. Subject satisfaction questionnaires were administered 3 weeks and 6 months after the last injection. Global aesthetic improvement and improvement on each treated zone as well as safety were evaluated.

Results: A high level of satisfaction was achieved throughout the study, with 96.5% of subjects at least satisfied with the full-facial aesthetic outcome at 3 weeks, and 92.9% at 6 months. More than 91% considered the treatment outcome to meet or surpass their expectations, and more than 94% would recommend the treatment to others. At Week 3, subject and investigator assessment showed aesthetic improvement for all subjects. The treatment was well tolerated.

Conclusion: The combination of BoNT-A (s.U) and HA fillers results in high patient satisfaction and in an overall improvement of aesthetic outcomes and quality of life.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Botulinum Toxins, Type A / administration & dosage*
  • Cosmetic Techniques*
  • Drug Combinations
  • Face*
  • Female
  • Follow-Up Studies
  • Humans
  • Hyaluronic Acid / administration & dosage*
  • Injections
  • Male
  • Middle Aged
  • Neuromuscular Agents / administration & dosage
  • Patient Satisfaction*
  • Quality of Life
  • Rejuvenation*
  • Skin Aging / drug effects*
  • Treatment Outcome
  • Viscosupplements / administration & dosage
  • Young Adult


  • Drug Combinations
  • Neuromuscular Agents
  • Viscosupplements
  • Hyaluronic Acid
  • Botulinum Toxins, Type A