Mammary Hibernoma: A Rare Entity

Arch Pathol Lab Med. 2015 Dec;139(12):1565-7. doi: 10.5858/arpa.2014-0318-RS.


Hibernoma arising in the breast is rare and may present as an asymptomatic mass or may be detected by screening mammography. Four histologic types have been identified: typical, myxoid variant, spindle cell variant, and the lipoma-like variant. The most common "typical variant" is composed of pale to eosinophilic multivacuolated cells with interspersed univacuolar cells. Hibernomas are universally benign and are not known to recur or have an aggressive behavior, even in incompletely excised lesions. Hence, their clinical importance lies in distinguishing them from other benign and malignant breast neoplasms as well as inflammatory conditions that come into the histologic or radiologic differential. This review discusses the clinical features, radiologic and histopathologic characteristics, ancillary studies, suggested pathogenesis, differential diagnosis, and treatment of and prognosis for these uncommon lesions.

Publication types

  • Review

MeSH terms

  • Breast / pathology*
  • Breast / surgery
  • Breast Neoplasms / pathology*
  • Breast Neoplasms / surgery
  • Diagnosis, Differential
  • Early Detection of Cancer
  • Female
  • Humans
  • Lipoma / pathology*
  • Lipoma / surgery
  • Mammography
  • Prognosis
  • Proteoglycans


  • Proteoglycans