Neurological disorders and celiac disease

Minerva Gastroenterol Dietol. 2016 Jun;62(2):197-206. Epub 2015 Nov 30.


Celiac disease (CD) determines neurologic manifestations in 10% of all CD patients. We describe the most common clinical manifestations as cerebellar ataxia, gluten encephalopathy, multiple sclerosis, peripheral neuropathies, sensorineural hearing loss, epilepsy, headache, depression, cognitive deficiencies and other less described clinical conditions. Our aim is to perform, as more as possible, a review about the most recent update on the topics in international literature. It is important to consider clinical neurological manifestations in celiac patients and to research these conditions also in the follow-up because they may start also one year after the start of gluten free diet (GFD) as peripheral neuropathy. The association with autism is analysed and possible new association with non-celiac gluten sensitivity (NCGS) are considered.

Publication types

  • Review

MeSH terms

  • Autistic Disorder / etiology
  • Celiac Disease / complications*
  • Depression / etiology
  • Humans
  • Nervous System Diseases / etiology*
  • Wheat Hypersensitivity / complications