Polycystic Ovary Syndrome and Metabolic Syndrome: The Worrisome Twosome?

Climacteric. 2016;19(1):7-16. doi: 10.3109/13697137.2015.1116505. Epub 2015 Dec 1.


By virtue of insulin resistance being the common etiology for polycystic ovary syndrome (PCOS) and metabolic syndrome, the cardiometabolic risks of these two syndromes are shared. The usual concerns of a PCOS patient are cosmetic or reproductive. However, there are more serious concerns past the reproductive age. Early treatment of insulin resistance, hypertension and hyperlipidemia reduces the long-term risk. This review highlights the unhealthy association of metabolic syndrome with PCOS and emphasizes the importance of early diagnosis, patient education and long-term follow-up beyond the reproductive age into menopause to prevent the long-term serious co-morbidities.

Keywords: Polycystic ovary syndrome; dyslipidemia; hyperandrogenemia; hypertension; insulin resistance; menopause; metabolic syndrome; sleep apnea.

Publication types

  • Review

MeSH terms

  • Dyslipidemias / complications
  • Female
  • Humans
  • Hypertension / complications
  • Insulin Resistance*
  • Metabolic Syndrome / complications*
  • Metabolic Syndrome / diagnosis
  • Obesity / complications
  • Patient Education as Topic
  • Polycystic Ovary Syndrome / complications*
  • Polycystic Ovary Syndrome / diagnosis
  • Practice Guidelines as Topic
  • Risk Factors
  • Sleep Apnea Syndromes / complications
  • World Health Organization