Rapid emergence and predominance of a broadly recognizing and fast-evolving norovirus GII.17 variant in late 2014

Nat Commun. 2015 Dec 2;6:10061. doi: 10.1038/ncomms10061.

Abstract

Norovirus genogroup II genotype 4 (GII.4) has been the predominant cause of viral gastroenteritis since 1996. Here we show that during the winter of 2014-2015, an emergent variant of a previously rare norovirus GII.17 genotype, Kawasaki 2014, predominated in Hong Kong and outcompeted contemporary GII.4 Sydney 2012 in hospitalized cases. GII.17 cases were significantly older than GII.4 cases. Root-to-tip and Bayesian BEAST analyses estimate GII.17 viral protein 1 (VP1) evolves one order of magnitude faster than GII.4 VP1. Residue substitutions and insertion occur in four of five inferred antigenic epitopes, suggesting immune evasion. Sequential GII.4-GII.17 infections are noted, implicating a lack of cross-protection. Virus bound to saliva of secretor histo-blood groups A, B and O, indicating broad susceptibility. This fast-evolving, broadly recognizing and probably immune-escaped emergent GII.17 variant causes severe gastroenteritis and hospitalization across all age groups, including populations who were previously less vulnerable to GII.4 variants; therefore, the global spread of GII.17 Kawasaki 2014 needs to be monitored.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Australia / epidemiology
  • Caliciviridae Infections / epidemiology
  • Caliciviridae Infections / virology*
  • Child
  • Child, Preschool
  • Disease Outbreaks
  • Evolution, Molecular*
  • Female
  • Gastroenteritis / epidemiology
  • Gastroenteritis / virology*
  • Genotype
  • Hong Kong / epidemiology
  • Humans
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Norovirus / classification
  • Norovirus / genetics*
  • Norovirus / isolation & purification*
  • Phylogeny
  • Seasons
  • Viral Proteins / genetics
  • Young Adult

Substances

  • Viral Proteins

Associated data

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