Nuclear Phosphatidylinositol Signaling: Focus on Phosphatidylinositol Phosphate Kinases and Phospholipases C

J Cell Physiol. 2016 Aug;231(8):1645-55. doi: 10.1002/jcp.25273. Epub 2015 Dec 28.


Phosphatidylinositol (PI) metabolism represents the core of a network of signaling pathways which modulate many cellular functions including cell proliferation, cell differentiation, apoptosis, and membrane trafficking. An array of kinases, phosphatases, and lipases acts on PI creating an important number of second messengers involved in different cellular processes. Although, commonly, PI signaling was described to take place at the plasma membrane, many evidences indicated the existence of a PI cycle residing in the nuclear compartment of eukaryotic cells. The discovery of this mechanism shed new light on many nuclear functions, such as gene transcription, DNA modifications, and RNA expression. As these two PI cycles take place independently of one another, understanding how nuclear lipid signaling functions and modulates nuclear output is fundamental in the study of many cellular processes. J. Cell. Physiol. 231: 1645-1655, 2016. © 2015 Wiley Periodicals, Inc.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle Checkpoints
  • Cell Differentiation
  • Cell Nucleus / enzymology*
  • Cell Nucleus / pathology
  • Cell Proliferation
  • Humans
  • Hydrolysis
  • Myelodysplastic Syndromes / enzymology
  • Myelodysplastic Syndromes / pathology
  • Neoplasms / enzymology
  • Neoplasms / pathology
  • Phosphatidylinositol 4,5-Diphosphate / metabolism
  • Phosphatidylinositols / metabolism*
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism*
  • Second Messenger Systems*
  • Transcription, Genetic
  • Type C Phospholipases / metabolism*


  • Phosphatidylinositol 4,5-Diphosphate
  • Phosphatidylinositols
  • Phosphotransferases (Alcohol Group Acceptor)
  • Type C Phospholipases