Synapsin Isoforms and Synaptic Vesicle Trafficking

Mol Cells. 2015 Nov;38(11):936-40. doi: 10.14348/molcells.2015.0233. Epub 2015 Nov 20.

Abstract

Synapsins were the first presynaptic proteins identified and have served as the flagship of the presynaptic protein field. Here we review recent studies demonstrating that different members of the synapsin family play different roles at presynaptic terminals employing different types of synaptic vesicles. The structural underpinnings for these functions are just beginning to be understood and should provide a focus for future efforts.

Keywords: neurotransmitter release; presynaptic terminals; synapsins; synaptic vesicles; vesicle trafficking.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Neurotransmitter Agents / metabolism
  • Phosphorylation / physiology
  • Presynaptic Terminals / metabolism*
  • Protein Isoforms / metabolism
  • Protein Transport / physiology
  • Synapsins / metabolism*
  • Synaptic Vesicles / metabolism*

Substances

  • Neurotransmitter Agents
  • Protein Isoforms
  • Synapsins