"WHAT'S BUGGING THE GUT IN OCD?" A REVIEW OF THE GUT MICROBIOME IN OBSESSIVE-COMPULSIVE DISORDER

Depress Anxiety. 2016 Mar;33(3):171-8. doi: 10.1002/da.22454. Epub 2015 Dec 2.

Abstract

The gut microbiome has become a topic of major interest as of late, with a new focus specifically on psychiatric disorders. Recent studies have revealed that variations in the composition of the gut microbiota may influence anxiety and mood and vice versa. Keeping the concept of this bidirectional "microbiota-gut-brain" axis in mind, this review aims to shed light on how these findings may also be implicated in obsessive-compulsive disorder (OCD); potentially outlining a novel etiological pathway of interest for future research in the field.

Keywords: OCD; anxiety; gut microbiota; gut-brain axis; inflammation; obsessive-compulsive disorder.

Publication types

  • Review

MeSH terms

  • Animals
  • Gastrointestinal Microbiome / immunology*
  • Humans
  • Obsessive-Compulsive Disorder / immunology*
  • Obsessive-Compulsive Disorder / microbiology*