Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis

doi:10.1186/s12944-015-0141-z

Review

. 2015 Dec 3:14:158.

doi: 10.1186/s12944-015-0141-z.

Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis

Xin Xu^{1

2}, Linlin Lu^{2

3}, Quanyong Dong^{1

2}, Xiaolin Li^{1

2}, Nannan Zhang^{1

2}, Yongning Xin^{4

5

6}, Shiying Xuan^{7

8

9}

Affiliations

¹ Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, China.
² Digestive Disease Key Laboratory of Qingdao, Qingdao, China.
³ Central Laboratories, Qingdao Municipal Hospital, Qingdao, China.
⁴ Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, China. xinyongning@163.com.
⁵ Digestive Disease Key Laboratory of Qingdao, Qingdao, China. xinyongning@163.com.
⁶ Central Laboratories, Qingdao Municipal Hospital, Qingdao, China. xinyongning@163.com.
⁷ Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, China. xuansydxy@163.com.
⁸ Digestive Disease Key Laboratory of Qingdao, Qingdao, China. xuansydxy@163.com.
⁹ Central Laboratories, Qingdao Municipal Hospital, Qingdao, China. xuansydxy@163.com.

PMID: 26631018
PMCID: PMC4668687
DOI: 10.1186/s12944-015-0141-z

Free PMC article

Review

Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis

Xin Xu et al. Lipids Health Dis. 2015.

Free PMC article

. 2015 Dec 3:14:158.

doi: 10.1186/s12944-015-0141-z.

Authors

Xin Xu^{1

2}, Linlin Lu^{2

3}, Quanyong Dong^{1

2}, Xiaolin Li^{1

2}, Nannan Zhang^{1

2}, Yongning Xin^{4

5

6}, Shiying Xuan^{7

8

9}

Affiliations

¹ Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, China.
² Digestive Disease Key Laboratory of Qingdao, Qingdao, China.
³ Central Laboratories, Qingdao Municipal Hospital, Qingdao, China.
⁴ Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, China. xinyongning@163.com.
⁵ Digestive Disease Key Laboratory of Qingdao, Qingdao, China. xinyongning@163.com.
⁶ Central Laboratories, Qingdao Municipal Hospital, Qingdao, China. xinyongning@163.com.
⁷ Department of Gastroenterology, Qingdao Municipal Hospital, Dalian Medical University, Qingdao, China. xuansydxy@163.com.
⁸ Digestive Disease Key Laboratory of Qingdao, Qingdao, China. xuansydxy@163.com.
⁹ Central Laboratories, Qingdao Municipal Hospital, Qingdao, China. xuansydxy@163.com.

PMID: 26631018
PMCID: PMC4668687
DOI: 10.1186/s12944-015-0141-z

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver disease that is closely related not only to genetic susceptibility but also to insulin resistance and highly linked with metabolic syndrome. In recent years, the prevalence of NAFLD has increased rapidly, paralleling the epidemic of type 2 diabetes mellitus and obesity leading to cardiovascular disease. It has been demonstrated that NAFLD is highly associated with atherosclerosis. With recently gained knowledge, it appears that NAFLD may induce insulin resistance, dyslipidemia, oxidative stress, inflammation, and fluctuation of adipokines associated with atherosclerosis. In this review, we aimed to summarize recent discoveries related to both NAFLD and atherosclerosis, and to identify possible mechanisms linking them.

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References

1. Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD single topic conference. Hepatology. 2003;37(5):1202–1219. doi: 10.1053/jhep.2003.50193. - DOI - PubMed
1. Angulo P, Lindor KD. Non-alcoholic fatty liver disease. J Gastroenterol Hepatol. 2002;17(Suppl):S186–S190. doi: 10.1046/j.1440-1746.17.s1.10.x. - DOI - PubMed
1. Angulo P. Obesity and nonalcoholic fatty liver disease. Nutr Rev. 2007;65(6 Pt 2):S57–S63. doi: 10.1301/nr.2007.jun.S57-S63. - DOI - PubMed
1. Dowman JK, Tomlinson JW, Newsome PN. Pathogenesis of non-alcoholic fatty liver disease. QJM. 2010;103(2):71–83. doi: 10.1093/qjmed/hcp158. - DOI - PMC - PubMed
1. Souza MR, Diniz Mde F, Medeiros-Filho JE, Araújo MS, et al. Metabolic syndrome and risk factors for non-alcoholic fatty liver disease. Arq Gastroenterol. 2012;49(1):89–96. doi: 10.1590/S0004-28032012000100015. - DOI - PubMed

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[1] Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD single topic conference. Hepatology. 2003;37(5):1202–1219. doi: 10.1053/jhep.2003.50193. - DOI - PubMed

[2] Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD single topic conference. Hepatology. 2003;37(5):1202–1219. doi: 10.1053/jhep.2003.50193. - DOI - PubMed

[3] Angulo P, Lindor KD. Non-alcoholic fatty liver disease. J Gastroenterol Hepatol. 2002;17(Suppl):S186–S190. doi: 10.1046/j.1440-1746.17.s1.10.x. - DOI - PubMed

[4] Angulo P, Lindor KD. Non-alcoholic fatty liver disease. J Gastroenterol Hepatol. 2002;17(Suppl):S186–S190. doi: 10.1046/j.1440-1746.17.s1.10.x. - DOI - PubMed

[5] Angulo P. Obesity and nonalcoholic fatty liver disease. Nutr Rev. 2007;65(6 Pt 2):S57–S63. doi: 10.1301/nr.2007.jun.S57-S63. - DOI - PubMed

[6] Angulo P. Obesity and nonalcoholic fatty liver disease. Nutr Rev. 2007;65(6 Pt 2):S57–S63. doi: 10.1301/nr.2007.jun.S57-S63. - DOI - PubMed

[7] Dowman JK, Tomlinson JW, Newsome PN. Pathogenesis of non-alcoholic fatty liver disease. QJM. 2010;103(2):71–83. doi: 10.1093/qjmed/hcp158. - DOI - PMC - PubMed

[8] Dowman JK, Tomlinson JW, Newsome PN. Pathogenesis of non-alcoholic fatty liver disease. QJM. 2010;103(2):71–83. doi: 10.1093/qjmed/hcp158. - DOI - PMC - PubMed

[9] Souza MR, Diniz Mde F, Medeiros-Filho JE, Araújo MS, et al. Metabolic syndrome and risk factors for non-alcoholic fatty liver disease. Arq Gastroenterol. 2012;49(1):89–96. doi: 10.1590/S0004-28032012000100015. - DOI - PubMed

[10] Souza MR, Diniz Mde F, Medeiros-Filho JE, Araújo MS, et al. Metabolic syndrome and risk factors for non-alcoholic fatty liver disease. Arq Gastroenterol. 2012;49(1):89–96. doi: 10.1590/S0004-28032012000100015. - DOI - PubMed

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Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis

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Research advances in the relationship between nonalcoholic fatty liver disease and atherosclerosis

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