The good and the bad faces of STAT1 in solid tumours

Cytokine. 2017 Jan;89:12-20. doi: 10.1016/j.cyto.2015.11.011. Epub 2015 Nov 26.


Signal transducer and activator of transcription (STAT) 1 is part of the Janus kinase (JAK)/STAT signalling cascade and is best known for its essential role in mediating responses to all types of interferons (IFN). STAT1 regulates a variety of cellular processes, such as antimicrobial activities, cell proliferation and cell death. It exerts important immune modulatory activities both in the innate and the adaptive arm of the immune system. Based on studies in mice and data from human patients, STAT1 is generally considered a tumour suppressor but there is growing evidence that it can also act as a tumour promoter. This review aims at contrasting the two faces of STAT1 in tumourigenesis and providing an overview on the current knowledge of the underlying mechanisms or pathways.

Keywords: Acquired therapy resistance; Cell proliferation and death; Cytokine signalling; Immune surveillance; Tumour suppressor.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptive Immunity*
  • Animals
  • Humans
  • Immunity, Innate*
  • Neoplasms / genetics
  • Neoplasms / immunology*
  • Neoplasms / pathology
  • STAT1 Transcription Factor / genetics
  • STAT1 Transcription Factor / immunology*
  • Signal Transduction / genetics
  • Signal Transduction / immunology*
  • Tumor Suppressor Proteins / genetics
  • Tumor Suppressor Proteins / immunology*


  • STAT1 Transcription Factor
  • STAT1 protein, human
  • Tumor Suppressor Proteins