Zwitterionic Cellulose Carbamate with Regioselective Substitution Pattern: A Coating Material Possessing Antimicrobial Activity

Macromol Biosci. 2016 Apr;16(4):522-34. doi: 10.1002/mabi.201500349. Epub 2015 Dec 3.


A polyzwitterion is synthesized by regioselective functionalization of cellulose possessing a uniform charge distribution. The positively charged ammonium group is present at position 6, while the negative charge of carboxylate is located at positions 2 and 3 of the repeating unit. The molecular structure of the biopolymer derivative is proved by NMR spectroscopy. This cellulose-based zwitterion is applied to several support materials by spin-coating and characterized by means of atomic force microscope, contact angle measurements, ellipsometry, and X-ray photoelectron spectroscopy. The coatings possess antimicrobial activity depending on the support materials (glass, titanium, tissue culture poly(styrene)) as revealed by confocal laser scanning microscopy and live/dead staining.

Keywords: E. coli; antimicrobial; cellulose; coating; zwitterion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / chemical synthesis*
  • Anti-Infective Agents / pharmacology
  • Bacterial Adhesion / drug effects*
  • Cellulose / analogs & derivatives
  • Cellulose / chemical synthesis*
  • Cellulose / pharmacology
  • Escherichia coli / drug effects*
  • Escherichia coli / growth & development
  • Glass / chemistry
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Polystyrenes / chemistry
  • Static Electricity
  • Stereoisomerism
  • Surface Properties
  • Titanium / chemistry


  • Anti-Infective Agents
  • Polystyrenes
  • Cellulose
  • Titanium