Fatty acids, eicosanoids and PPAR gamma

Eur J Pharmacol. 2016 Aug 15;785:44-49. doi: 10.1016/j.ejphar.2015.11.004. Epub 2015 Nov 26.

Abstract

Peroxisome proliferator-activated receptor γ (PPARγ) belongs to the family of nuclear nuclear receptors and is mainly expressed in adipose tissue, hematopoietic cells and the large intestine. Contrary to other nuclear receptors that mainly bind a single specific ligand, there are numerous natural PPARγ ligands, in particular fatty acids or their derivatives called eicosanoids. PPARγ have pleiotropic functions: (i) glucose and lipid metabolism regulation, (ii) anti-inflammatory properties, (iii) oxidative stress inhibition, (iv) improvement of endothelial function. Its role has been mainly studied by the use synthetic agonists. In this review, we will focus on the effects of PPARγ mediated through fatty acids and how these have beneficial health properties.

Keywords: Eicosanoids; Leukotrienes; PPAR gamma; Polyunsaturated fatty acids; Prostaglandins.

Publication types

  • Review

MeSH terms

  • Animals
  • Eicosanoids / metabolism*
  • Fatty Acids / metabolism*
  • Gene Expression Regulation
  • Humans
  • PPAR gamma / chemistry
  • PPAR gamma / metabolism*

Substances

  • Eicosanoids
  • Fatty Acids
  • PPAR gamma