Abstract
Two new glabretal triterpenes, pancastatins A (1) and B (2), were isolated from the immature fruits of Poncirus trifoliata. Their chemical structures were elucidated by spectroscopic analyses including one- and two-dimensional NMR and high-resolution electrospray ionization mass spectrometry. Compounds 1 and 2 exhibited selective cytotoxicity against PANC-1 pancreatic cancer cells under low-glucose stress conditions.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Dose-Response Relationship, Drug
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Fruit / chemistry*
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Glucose / metabolism
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Humans
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Molecular Conformation
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Oxidative Stress
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Poncirus / chemistry*
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Structure-Activity Relationship
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Triterpenes
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pancastatin A
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pancastatin B
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Glucose