Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication

Viruses. 2015 Dec 1;7(12):6233-40. doi: 10.3390/v7122934.

Abstract

The current outbreak of Ebola virus (EBOV) in West Africa has claimed the lives of more than 15,000 people and highlights an urgent need for therapeutics capable of preventing virus replication. In this study we screened known nucleoside analogues for their ability to interfere with EBOV replication. Among them, the cytidine analogue β-d-N4-hydroxycytidine (NHC) demonstrated potent inhibitory activities against EBOV replication and spread at non-cytotoxic concentrations. Thus, NHC constitutes an interesting candidate for the development of a suitable drug treatment against EBOV.

Keywords: Ebola; Filovirus; Marburg; antiviral; inhibitors; polymerase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / pharmacology*
  • Antiviral Agents / toxicity
  • Chlorocebus aethiops
  • Cytidine / analogs & derivatives*
  • Cytidine / pharmacology
  • Cytidine / toxicity
  • Ebolavirus / drug effects*
  • Ebolavirus / physiology*
  • Vero Cells
  • Virus Replication / drug effects*

Substances

  • Antiviral Agents
  • N(4)-hydroxycytidine
  • Cytidine