Treatment of gastrointestinal autonomic neuropathy

Diabetologia. 2016 Mar;59(3):409-13. doi: 10.1007/s00125-015-3828-9. Epub 2015 Dec 3.


The symptoms caused by gastrointestinal autonomic neuropathy in diabetes mellitus is important to highlight since it affects a large proportion of people with diabetes, regardless of whether this is type 1 or type 2. Gastroparesis and general signs of bowel dysfunction, such as constipation, diarrhoea and abdominal pain are most often encountered and involve both pharmacological and non-pharmacological treatment options. This mini-review summarises a presentation given at the 'Diagnosis and treatment of autonomic diabetic neuropathy in the gut' symposium at the 2015 annual meeting of the EASD. It is accompanied by another mini-review on a topic from this symposium (by Azpiroz and Malagelada, DOI: 10.1007/s00125-015-3831-1 ) and a commentary by the Session Chair, Péter Kempler (DOI: 10.1007/s00125-015-3826-y ).

Keywords: Abdominal pain; Autonomic neuropathy; Constipation; Diarrhoea; Gastric electrical stimulation; Gastroparesis.

Publication types

  • Review

MeSH terms

  • Abdominal Pain / drug therapy
  • Abdominal Pain / physiopathology
  • Abdominal Pain / therapy
  • Animals
  • Autonomic Nervous System Diseases / drug therapy*
  • Autonomic Nervous System Diseases / physiopathology
  • Autonomic Nervous System Diseases / therapy*
  • Diabetic Neuropathies / drug therapy*
  • Diabetic Neuropathies / physiopathology
  • Diabetic Neuropathies / therapy*
  • Gastroparesis / drug therapy
  • Gastroparesis / physiopathology
  • Gastroparesis / therapy
  • Humans