Cancer immunosurveillance: role of patrolling monocytes

Cell Res. 2016 Jan;26(1):3-4. doi: 10.1038/cr.2015.144. Epub 2015 Dec 4.

Abstract

Classical inflammatory monocytes and their derivative macrophages promote tumor metastasis whereas CD8(+) T and NK cells restrict tumor growth. In a recent paper published in Science, Hanna and colleagues demonstrate that another monocyte population, nonclassical patrolling monocytes, is enriched in the microvasculature of tumor-challenged lung and reduces tumor metastasis by recruiting NK cells.

MeSH terms

  • Animals
  • CD8 Antigens / immunology
  • Chemokines / immunology
  • Humans
  • Immunity, Cellular
  • Killer Cells, Natural / immunology*
  • Lung / blood supply
  • Lung / immunology*
  • Lung Neoplasms / blood supply
  • Lung Neoplasms / immunology*
  • Lung Neoplasms / secondary*
  • Monocytes / immunology*
  • Neoplasm Metastasis / immunology

Substances

  • CD8 Antigens
  • Chemokines