An Efficient and Facile Method for the Synthesis of Benzimidazoisoquinoline Derivatives via a Multicomponent Reaction

ACS Comb Sci. 2016 Jan 11;18(1):65-9. doi: 10.1021/acscombsci.5b00145. Epub 2015 Dec 18.

Abstract

Two series of benzimidazoisoquinoline and fused benzimidazoisoquinoline-benzimidazole derivatives have been synthesized using an efficient one-pot procedure. This process involves an intramolecular nucleophilic substitution reaction and provides facile access to two series of complexes and potentially interesting biologically active scaffolds.

Keywords: benzimidazoisoquinoline; benzimidazole; multicomponent reactions (MCRs); nucleophilic substitution reaction; one-pot.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzimidazoles / chemical synthesis*
  • Benzimidazoles / chemistry
  • Combinatorial Chemistry Techniques / economics
  • Combinatorial Chemistry Techniques / methods*
  • Halogenation
  • Isoquinolines / chemical synthesis*
  • Isoquinolines / chemistry
  • Small Molecule Libraries / chemical synthesis*
  • Small Molecule Libraries / chemistry

Substances

  • Benzimidazoles
  • Isoquinolines
  • Small Molecule Libraries