Effect of endothelin on renal function in rats

Eur J Pharmacol. 1989 Apr 12;163(1):187-9. doi: 10.1016/0014-2999(89)90417-2.


The effect of synthetic porcine endothelin on glomerular filtration rate, renal plasma flow and electrolyte excretion was studied in rats. Endothelin, 1 nmol/kg body weight given as a bolus, induced a transient decrease in glomerular filtration rate (72%) and in renal plasma flow (76%) as well as in sodium excretion, accompanied by a sustained increase in renal vascular resistance. This dose had no sustained effect on mean arterial pressure. It is concluded that endothelin induces a marked decrease in glomerular filtration rate and renal perfusion. This peptide could play a role in the alterations in renal function observed after renal injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Endothelins
  • Glomerular Filtration Rate / drug effects
  • Kidney / drug effects*
  • Male
  • Peptides / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Renal Circulation / drug effects
  • Urodynamics / drug effects


  • Endothelins
  • Peptides