Mice bearing the ob/ob mutation have impaired immunity

Int Arch Allergy Appl Immunol. 1978;57(3):263-8. doi: 10.1159/000232111.


The obese mutant mouse C57BL/6J ob/ob showed impaired ability to reject skin grafts or react to a contact-sensitising agent in comparison with littermate controls (either +/ob or +/+). Ability of spleen cells from mice bearing the ob/ob mutation to produce a graft-versus-host reaction in C57BL/6J X DBA/2J F1 hybrid mice was not impaired.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Dermatitis, Contact
  • Female
  • Graft Survival
  • Graft vs Host Reaction
  • Immunity, Cellular*
  • Male
  • Mice
  • Mice, Obese
  • Models, Biological
  • Skin Transplantation*
  • Transplantation, Homologous