Prognostic Value of FDG-PET/CT Total Lesion Glycolysis for Patients with Resectable Distal Bile Duct Adenocarcinoma

Anticancer Res. 2015 Dec;35(12):6985-91.


Aim: We investigated the prognostic value of clinicopathological factors in patients with a distal bile duct adenocarcinoma after curative resection.

Patients and methods: This retrospective study included 25 patients who underwent (18)F-fluorodeoxyglucose positron-emission tomography/computed tomography (FDG-PET/CT) before surgery. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured using FDG-PET/CT. FDG-PET/CT parameters and other clinicopathological factors were assessed to evaluate survival.

Results: Univariate survival analysis showed that high TLG, high MTV, and high SUVmax were significant prognostic predictors for poor overall survival. For progression-free survival, high TLG and large tumor size were significant predictors for a poor prognosis. After multivariate survival analysis, only high TLG was an independent prognostic predictor for poor overall survival (p=0.025).

Conclusion: Preoperative assessment of TLG by FDG-PET/CT might be a useful prognostic predictor in patients with a distal bile duct adenocarcinoma after curative resection.

Keywords: cholangiocarcinoma; distal bile duct; positron-emission tomography; prognosis; total lesion glycolysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Bile Duct Neoplasms / diagnosis*
  • Bile Duct Neoplasms / metabolism
  • Bile Duct Neoplasms / surgery
  • Cholangiocarcinoma / diagnosis*
  • Cholangiocarcinoma / metabolism
  • Cholangiocarcinoma / surgery
  • Female
  • Fluorodeoxyglucose F18
  • Glycolysis
  • Humans
  • Male
  • Middle Aged
  • Positron-Emission Tomography
  • Prognosis
  • Radiopharmaceuticals
  • Retrospective Studies
  • Survival Analysis
  • Tomography, X-Ray Computed
  • Tumor Burden


  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18