Genomic changes during evolution of animal parasitism in eukaryotes

Curr Opin Genet Dev. 2015 Dec;35:86-92. doi: 10.1016/j.gde.2015.11.001. Epub 2015 Nov 27.


Understanding how pathogens have evolved to survive in close association with their hosts is an important step in unraveling the biology of host-pathogen interactions. Comparative genomics is a powerful tool to approach this problem as an increasing number of genomes of multiple pathogen species and strains become available. The ever-growing catalog of genome sequences makes comparison of organisms easier, but it also allows us to reconstitute the evolutionary processes occurring at the genomic level that may have led to the acquisition of pathogenic or parasitic mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Evolution
  • Evolution, Molecular
  • Genome, Protozoan / genetics*
  • Genomics*
  • Host-Pathogen Interactions / genetics*
  • Parasites / genetics*
  • Parasites / pathogenicity*