Cardiac contractility modulation signals improve exercise intolerance and maladaptive regulation of cardiac key proteins for systolic and diastolic function in HFpEF

Int J Cardiol. 2016 Jan 15:203:1061-6. doi: 10.1016/j.ijcard.2015.10.208. Epub 2015 Oct 27.

¹ Charité-University-Medicine Berlin, Campus Rudolf Virchow, Department of Cardiology, Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany; DZHK (German Center for Cardiovascular Research), partner site Berlin, Germany. Electronic address: carsten.tschoepe@charite.de.
² Charité-University-Medicine Berlin, Campus Rudolf Virchow, Department of Cardiology, Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany; DZHK (German Center for Cardiovascular Research), partner site Berlin, Germany.
³ Charité-University-Medicine Berlin, Campus Rudolf Virchow, Department of Cardiology, Berlin, Germany.
⁴ Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany.
⁵ Charité-University-Medicine Berlin, Campus Benjamin Franklin, Department of Cardiology, Berlin, German.
⁶ Heart and Vascular Center (HGZ), Bad Bevensen, Germany.
⁷ Medical College of Wisconsin, Milwaukee, USA.
⁸ Department of Cardiovascular Physiology, Institute of Physiology, Ruhr University Bochum, Bochum, Germany.
⁹ Charité-University-Medicine Berlin, Campus Rudolf Virchow, Department of Cardiology, Berlin, Germany; DZHK (German Center for Cardiovascular Research), partner site Berlin, Germany; Department of Cardiology, Deutsches Herzzentrum Berlin (DHZB), Berlin, Germany.

No abstract available

Keywords: Ca(2+) modulation; Cardiac contractility modulation; HFpEF; Proteomics; Reverse remodeling; Titin.

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