A New Golden Age of Natural Products Drug Discovery

doi:10.1016/j.cell.2015.11.031

. 2015 Dec 3;163(6):1297-300.

doi: 10.1016/j.cell.2015.11.031.

A New Golden Age of Natural Products Drug Discovery

Ben Shen¹

Affiliations

Affiliation

¹ Department of Chemistry, The Scripps Research Institute, Jupiter, FL 33458, USA; Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA; Natural Products Library Initiative at The Scripps Research Institute, The Scripps Research Institute, Jupiter, FL 33458, USA; Xiangya International Academy of Translational Medicine, Central South University, Changsha, Hunan 410013, China. Electronic address: shenb@scripps.edu.

PMID: 26638061
PMCID: PMC5070666
DOI: 10.1016/j.cell.2015.11.031

Free PMC article

A New Golden Age of Natural Products Drug Discovery

Ben Shen. Cell. 2015.

Free PMC article

. 2015 Dec 3;163(6):1297-300.

doi: 10.1016/j.cell.2015.11.031.

Author

Ben Shen¹

Affiliation

¹ Department of Chemistry, The Scripps Research Institute, Jupiter, FL 33458, USA; Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA; Natural Products Library Initiative at The Scripps Research Institute, The Scripps Research Institute, Jupiter, FL 33458, USA; Xiangya International Academy of Translational Medicine, Central South University, Changsha, Hunan 410013, China. Electronic address: shenb@scripps.edu.

PMID: 26638061
PMCID: PMC5070666
DOI: 10.1016/j.cell.2015.11.031

Abstract

The 2015 Nobel Prize in Physiology or Medicine has been awarded to William C. Campbell, Satoshi Omura, and Youyou Tu for the discovery of avermectins and artemisinin, respectively, therapies that revolutionized the treatment of devastating parasite diseases. With the recent technological advances, a New Golden Age of natural products drug discovery is dawning.

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Figures

Figure 1. Discovery of avermectin from *S. avermitilis* and artemisinin from *A. annua*
A. Soil samples Omura collected near a golf course, from which the avermectin producing *S. avermitilis* was isolated, and Campbell discovered avermectins and developed them into ivermectin. B. The ancient Chinese medicine *“Handbook of Prescriptions for Emergencies”* that inspired Tu to discovery artimisinin from the *A. annua* L. plants.

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References

1. Bouslimani A, Sanchez LM, Garg N, Dorrestein PC. Nat. Prod. Rep. 2014;31:718–729. - PMC - PubMed
1. Campbell WC. Med. Res. Rev. 1993;13:61–79. - PubMed
1. Campbell WC, Fisher MH, Stapley EO, Albers-Schonberg G, Jacob TA. Science. 1983;221:823–828. - PubMed
1. Charlop-Powers Z, Owen JG, Reddy BVB, Ternei MA, Brady SF. Proc. Natl. Acad. Sci. U.S.A. 2014;111:3757–3762. - PMC - PubMed
1. Ikeda H, Nonomiya T, Usami M, Ohta T, Omura S. Proc. Natl. Acad. Sci. U.S.A. 1999;96:9509–9514. - PMC - PubMed

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[1] Bouslimani A, Sanchez LM, Garg N, Dorrestein PC. Nat. Prod. Rep. 2014;31:718–729. - PMC - PubMed

[2] Bouslimani A, Sanchez LM, Garg N, Dorrestein PC. Nat. Prod. Rep. 2014;31:718–729. - PMC - PubMed

[3] Campbell WC. Med. Res. Rev. 1993;13:61–79. - PubMed

[4] Campbell WC. Med. Res. Rev. 1993;13:61–79. - PubMed

[5] Campbell WC, Fisher MH, Stapley EO, Albers-Schonberg G, Jacob TA. Science. 1983;221:823–828. - PubMed

[6] Campbell WC, Fisher MH, Stapley EO, Albers-Schonberg G, Jacob TA. Science. 1983;221:823–828. - PubMed

[7] Charlop-Powers Z, Owen JG, Reddy BVB, Ternei MA, Brady SF. Proc. Natl. Acad. Sci. U.S.A. 2014;111:3757–3762. - PMC - PubMed

[8] Charlop-Powers Z, Owen JG, Reddy BVB, Ternei MA, Brady SF. Proc. Natl. Acad. Sci. U.S.A. 2014;111:3757–3762. - PMC - PubMed

[9] Ikeda H, Nonomiya T, Usami M, Ohta T, Omura S. Proc. Natl. Acad. Sci. U.S.A. 1999;96:9509–9514. - PMC - PubMed

[10] Ikeda H, Nonomiya T, Usami M, Ohta T, Omura S. Proc. Natl. Acad. Sci. U.S.A. 1999;96:9509–9514. - PMC - PubMed

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A New Golden Age of Natural Products Drug Discovery

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