Genome Sequencing Fishes out Longevity Genes

Cell. 2015 Dec 3;163(6):1312-3. doi: 10.1016/j.cell.2015.11.040.


Understanding the molecular basis underlying aging is critical if we are to fully understand how and why we age-and possibly how to delay the aging process. Up until now, most longevity pathways were discovered in invertebrates because of their short lifespans and availability of genetic tools. Now, Reichwald et al. and Valenzano et al. independently provide a reference genome for the short-lived African turquoise killifish, establishing its role as a vertebrate system for aging research.

Publication types

  • Comment

MeSH terms

  • Animals
  • Biological Evolution*
  • Female
  • Humans
  • Killifishes / genetics*
  • Male
  • Sex Chromosomes*