Get in LINE: Competition for Newly Minted Retrotransposon Proteins at the Ribosome

Stephen N Floor; Jennifer A Doudna

doi:10.1016/j.molcel.2015.11.014

Get in LINE: Competition for Newly Minted Retrotransposon Proteins at the Ribosome

Mol Cell. 2015 Dec 3;60(5):712-714. doi: 10.1016/j.molcel.2015.11.014.

Authors

Stephen N Floor¹, Jennifer A Doudna²

Affiliations

¹ Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
² Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Innovative Genomics Initiative, University of California, Berkeley, Berkeley, CA 94720, USA; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Electronic address: doudna@berkeley.edu.

PMID: 26638173
DOI: 10.1016/j.molcel.2015.11.014

Abstract

In this issue, Ahl et al. (2015) and Doucet et al. (2015) illuminate structural and functional features of substrates that promote integration of RNA molecules into the human genome by LINE retrotransposons, contributing to the ∼ 50% of the human genome that has been colonized by mobile genetic elements.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Alu Elements*
Animals
Humans
Long Interspersed Nucleotide Elements*
Poly A / metabolism*
RNA / chemistry*
RNA, Messenger / chemistry*
Ribosomes / metabolism*
Signal Recognition Particle / chemistry*

Substances

RNA, Messenger
Signal Recognition Particle
Poly A
RNA

Grants and funding

Howard Hughes Medical Institute/United States