Clinical and economic impact of antimicrobial stewardship interventions with the FilmArray blood culture identification panel

Diagn Microbiol Infect Dis. 2016 Feb;84(2):159-64. doi: 10.1016/j.diagmicrobio.2015.10.023. Epub 2015 Nov 11.

Abstract

The purpose of this study was to evaluate the impact of the FilmArray Blood Culture Identification (BCID) Panel on the management of patients with blood cultures growing gram positive cocci and Candida. We retrospectively compared clinical and economic outcomes between patients during the BCID testing period and a matched historical control group before BCID testing was introduced. A total of 84 BCID patients were matched to 252 historical controls. BCID identification of coagulase negative staphylococci contaminants resulted in shorter post-culture length of stay (P < 0.008) and saved roughly $30,000 per 100 patients tested. The BCID led to shorter duration of empirical vancomycin for patients with contaminated blood cultures (P = 0.005) and methicillin-susceptible Staphylococcus aureus bacteremia (P < 0.001). Patients with vancomycin-resistant enterococcal bacteremia received active therapy earlier than historical controls (P = 0.047). The BCID, coupled with antimicrobial stewardship intervention, was a cost effective tool to improve patient care.

Keywords: Antimicrobial stewardship; Bloodstream infection; Molecular diagnostics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anti-Bacterial Agents / economics
  • Anti-Bacterial Agents / therapeutic use*
  • Blood / microbiology*
  • Costs and Cost Analysis*
  • Drug Utilization / economics
  • Drug Utilization / standards*
  • Female
  • Humans
  • Length of Stay
  • Male
  • Middle Aged
  • Molecular Diagnostic Techniques / economics
  • Molecular Diagnostic Techniques / methods*
  • Non-Randomized Controlled Trials as Topic
  • Sepsis / diagnosis*
  • Sepsis / drug therapy*
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents