Galectin-3 as a Potential Target to Prevent Cancer Metastasis

Clin Med Insights Oncol. 2015 Nov 25;9:113-21. doi: 10.4137/CMO.S29462. eCollection 2015.

Abstract

Interactions between two cells or between cell and extracellular matrix mediated by protein-carbohydrate interactions play pivotal roles in modulating various biological processes such as growth regulation, immune function, cancer metastasis, and apoptosis. Galectin-3, a member of the β-galactoside-binding lectin family, is involved in fibrosis as well as cancer progression and metastasis, but the detailed mechanisms of its functions remain elusive. This review discusses its structure, carbohydrate-binding properties, and involvement in various aspects of tumorigenesis and some potential carbohydrate ligands that are currently investigated to block galectin-3 activity.

Keywords: TF disaccharide; angiogenesis; apoptosis; galectin-3; tumorigenesis.

Publication types

  • Review