Pharmacotherapeutic interventions for cocaine abuse. Matching patients to treatments

J Nerv Ment Dis. 1989 Jul;177(7):379-89. doi: 10.1097/00005053-198907000-00001.


Cocaine abuse treatment has begun to use a variety of adjunctive pharmacotherapies. These medications have been used for both acute crash symptoms and long-term prevention of relapse. A phasic model of recovery was integrated with a patient typology to formulate guidelines for using these rapidly evolving pharmacotherapies. The phases are crash, with-drawal, and extinction, and the patient typology includes psychiatric vulnerability and severity of cocaine abuse as contributors to the neuroadaptation that requires pharmacological amelioration. These guidelines address five issues: whom to treat, when to treat, what treatments are available, where to initiate and maintain treatment, and how to match patients to treatment options.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Bipolar Disorder / complications
  • Bipolar Disorder / drug therapy
  • Clinical Protocols
  • Cocaine*
  • Female
  • Humans
  • Mood Disorders / complications
  • Mood Disorders / drug therapy
  • Pregnancy
  • Pregnancy Complications
  • Risk Factors
  • Substance-Related Disorders / complications
  • Substance-Related Disorders / drug therapy*
  • Time Factors


  • Cocaine