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Clinical Trial
. 2015 Dec 7;10(12):e0144420.
doi: 10.1371/journal.pone.0144420. eCollection 2015.

Clinicopathological Characteristics and Survival Outcomes of Primary Signet Ring Cell Carcinoma in the Stomach: Retrospective Analysis of Single Center Database

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Free PMC article
Clinical Trial

Clinicopathological Characteristics and Survival Outcomes of Primary Signet Ring Cell Carcinoma in the Stomach: Retrospective Analysis of Single Center Database

Xiaowen Liu et al. PLoS One. .
Free PMC article

Abstract

Purpose: To investigate the clinicopathological features and prognosis of signet ring cell carcinoma of the stomach (SRC).

Methods: A total of 1464 gastric cancer patients who underwent curative gastrectomy from 2000 to 2008 at a single center were evaluated. Signet ring cell carcinoma (SRC) was defined as the presence of at least 50% signet ring cells in the pathologic specimen. The clinicopathological parameters and prognosis of SRC were analyzed by comparing with non-signet ring cell carcinoma (NSRC).

Results: Of 1464 patients, 138 patients (9.4%) were classified as SRC. There were significant differences in gender, age, tumor location, TNM stage, p21 expression, and p53 expression between SRC and NSRC. The 5-year survival rates of SRC and NSRC were 36.2% and 49.5%, respectively. The prognosis of SRC was poorer than that of NSRC (P <0.001). Multivariate analysis showed that SRC histology was an independent factor for poor prognosis (P <0.001).

Conclusion: Patients with SRC tend to present with a more advanced stage and poorer prognosis than patients with other types of gastric carcinoma.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Positive expression of biological markers by immunohistochemistry in gastric cancer tissue.
A) Positive expression of p21. B) Positive expression of p53. C) Positive expression of c-myc. D) Positive expression of EGFR.
Fig 2
Fig 2. Kaplan-Meier survival curves by histological type.
There were significant differences between SRC and NSRC (P <0.001).
Fig 3
Fig 3. Comparison of survival according to tumor stage.
There were significant differences between SRC and NSRC according to stage III (P <0.001).

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Grant support

This research is supported by grants from the Shanghai Committee of Science and Technology Funds (Contract grant numbers: 14ZR1407800, 124119a4302), and the National Natural Science Foundation of China (81502027). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of manuscript.
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