The global burden of major infectious complications following prostate biopsy

Epidemiol Infect. 2016 Jun;144(8):1784-91. doi: 10.1017/S0950268815002885. Epub 2015 Dec 9.


We present a systematic review providing estimates of the overall and regional burden of infectious complications following prostate biopsy. A directly standardized prevalence estimate was used because it reflects the burden of disease more explicitly. Complications included sepsis, hospitalization, bacteraemia, bacteriuria, and acute urinary retention after biopsy. There were 165 articles, comprising 162 577 patients, included in the final analysis. Our findings demonstrate that transrectal biopsy was associated with a higher burden of hospitalization (1·1% vs. 0·9%) and sepsis (0·8% vs. 0·1%) compared to transperineal biopsy, while acute urinary retention was more prevalent after transperineal than transrectal biopsy (4·2% vs. 0·9%). The differences were statistically non-significant because of large heterogeneity across countries. We also demonstrate and discuss regional variations in complication rates, with Asian studies reporting higher rates of sepsis and hospitalization.

Keywords: Infection; post-operative complications; prostate biopsy; prostatic neoplasms; transperineal; transrectal.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Biopsy / adverse effects*
  • Communicable Diseases / epidemiology*
  • Cost of Illness*
  • Global Health
  • Humans
  • Male
  • Prevalence
  • Prostatic Diseases / diagnosis*
  • Urinary Retention / epidemiology