Frequency of IWOS Suggestive Ocular Signs in Slovenian Uveitis Patients with Confirmed Pulmonary Sarcoidosis

Ocul Immunol Inflamm. 2016 Dec;24(6):660-664. doi: 10.3109/09273948.2015.1063669. Epub 2015 Dec 8.


Purpose: To investigate the prevalence of suggestive signs for ocular sarcoidosis proposed by the International Workshop on Ocular Sarcoidosis (IWOS) in patients with sarcoidosis-associated uveitis.

Methods: A retrospective study included 53 patients (77% female), with uveitis, who were seen in the period of 2010-2013 at the University Eye Hospital Ljubljana, Slovenia. All patients had confirmed pulmonary sarcoidosis based on clinical presentation, imaging and lung biopsy according to the ATS/ERS criteria. The presence of the seven clinical signs, suggested by the IWOS was determined in 47 patients with sufficient clinical data.

Results: Patients commonly exhibited bilaterality (79%), keratic precipitates/iris nodules (49%), and multiple chorioretinal peripheral lesions (36%). Three or more signs were observed in 40% (19/47) of patients or 79% (11/14) of patients with primary ocular involvement.

Conclusions: Results add to the validation of IWOS criteria and emphasize the high percentage of at least three suggestive for ocular sarcoidosis in patients with primary ocular involvement.

Keywords: Chorioretinal lesions; granulomatous uveitis; ocular sarcoidosis; sarcoidosis; sarcoidosis-associated uveitis.

MeSH terms

  • Eye / pathology*
  • Female
  • Humans
  • Male
  • Retrospective Studies
  • Sarcoidosis, Pulmonary / complications*
  • Slovenia
  • Uveitis / complications*
  • Uveitis / diagnosis*