Comparison of intraoperative versus 24 hour antibiotic prophylaxis in total joint replacement. A controlled prospective study

Orthop Rev. 1989 Jun;18(6):694-6.


One hundred and ninety-six consecutive total joint recipients, including unilateral and bilateral procedures, were studied. Patients were randomly assigned to receive one of two prophylactic protocols. Group A (98 patients) received two intraoperative doses of cefuroxime (1500 mg and 750 mg) intravenously and continued cefuroxime for 24 hours postoperatively (750 mg every eight hours intravenous piggy back). Group B (98 patients) received two intraoperative intravenous doses of cefuroxime (1500 mg and 750 mg) and no postoperative doses. The opening or closing surgical culture was positive for five patients in Group A and 10 patients in Group B. None of these patients had a postoperative infection. Patients were followed for a minimum of one year after surgery. No deep wound infection was reported for either group.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cefuroxime / administration & dosage*
  • Cephalosporins / administration & dosage*
  • Female
  • Hip Prosthesis*
  • Humans
  • Infusions, Intravenous
  • Intraoperative Care / methods*
  • Knee Prosthesis*
  • Male
  • Middle Aged
  • Postoperative Care / methods*
  • Prospective Studies
  • Random Allocation
  • Time Factors


  • Cephalosporins
  • Cefuroxime