3D surface-based registration of ultrasound and histology in prostate cancer imaging

Stefan G Schalk; Arnoud Postema; Tamerlan A Saidov; Libertario Demi; Martijn Smeenge; Jean J M C H de la Rosette; Hessel Wijkstra; Massimo Mischi

doi:10.1016/j.compmedimag.2015.11.001

3D surface-based registration of ultrasound and histology in prostate cancer imaging

Comput Med Imaging Graph. 2016 Jan:47:29-39. doi: 10.1016/j.compmedimag.2015.11.001. Epub 2015 Dec 1.

Authors

Stefan G Schalk¹, Arnoud Postema², Tamerlan A Saidov³, Libertario Demi³, Martijn Smeenge², Jean J M C H de la Rosette², Hessel Wijkstra⁴, Massimo Mischi³

Affiliations

¹ Department of Electrical Engineering, Eindhoven University of Technology, Postbus 513, 5600 MB Eindhoven, The Netherlands. Electronic address: s.g.schalk@tue.nl.
² Department of Urology, AMC University Hospital, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
³ Department of Electrical Engineering, Eindhoven University of Technology, Postbus 513, 5600 MB Eindhoven, The Netherlands.
⁴ Department of Electrical Engineering, Eindhoven University of Technology, Postbus 513, 5600 MB Eindhoven, The Netherlands; Department of Urology, AMC University Hospital, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

PMID: 26647110
DOI: 10.1016/j.compmedimag.2015.11.001

Abstract

Several transrectal ultrasound (TRUS)-based techniques aiming at accurate localization of prostate cancer are emerging to improve diagnostics or to assist with focal therapy. However, precise validation prior to introduction into clinical practice is required. Histopathology after radical prostatectomy provides an excellent ground truth, but needs accurate registration with imaging. In this work, a 3D, surface-based, elastic registration method was developed to fuse TRUS images with histopathologic results. To maximize the applicability in clinical practice, no auxiliary sensors or dedicated hardware were used for the registration. The mean registration errors, measured in vitro and in vivo, were 1.5±0.2 and 2.1±0.5mm, respectively.

Keywords: 3D registration; Deformable model; Elastic registration; Histology; Prostate; Ultrasound.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms*
Humans
Image Interpretation, Computer-Assisted
Imaging, Three-Dimensional*
Male
Prostate / diagnostic imaging*
Prostate / pathology
Prostatic Neoplasms / diagnostic imaging*
Prostatic Neoplasms / pathology
Ultrasonography