Targeting Transient Receptor Potential Canonical Channels for Diseases of the Nervous System

Abstract

Background: Ca2+ influx plays an essential role in the physiological and pathophysiologic processes of several nervous system diseases. The transient receptor-potential channels (TRPCs) form a family of voltage -sensitive calcium ion channels.

Objective: In this review, we will discuss the importance of transient receptor potential canonical (TRPC) channels, which is a crucial family of calcium channels. This article reviews the role of TRPC channels in the pathogenesis of diseases such as brain hemorrhage, hemorrhagic transformation after cerebral infarction, subarachnoid hemorrhage, and brain injury.

Results: TRPC has especially high expression in the central nervous system (CNS), and was involved in several physiological functions. The TRPC family is associated with cerebral vasospasm after subarachnoid hemorrhage, neuronal damage after intracerebral hemorrhage, NMDA cytotoxicity in cerebral ischemia, nervous system tumors, neurodegenerative diseases, neural addiction and other diseases.

Conclusion: The TRPC family has rich functionality and is widely distributed, with different functions in various nervous system diseases.

Keywords: Brain injury; Ca2+; TRPCs; hemorrhagic transformation; intracerebral hemorrhage; nerve system; subarachnoid hemorrhage.