Evaluation of Retinal Nerve Fiber Layer and Ganglion Cell Complex in Patients with Optic Neuritis or Neuromyelitis Optica Spectrum Disorders Using Optical Coherence Tomography in a Chinese Cohort

Guohong Tian; Zhenxin Li; Guixian Zhao; Chaoyi Feng; Mengwei Li; Yongheng Huang; Xinghuai Sun

doi:10.1155/2015/832784

Evaluation of Retinal Nerve Fiber Layer and Ganglion Cell Complex in Patients with Optic Neuritis or Neuromyelitis Optica Spectrum Disorders Using Optical Coherence Tomography in a Chinese Cohort

J Ophthalmol. 2015:2015:832784. doi: 10.1155/2015/832784. Epub 2015 Nov 15.

Authors

Guohong Tian¹, Zhenxin Li², Guixian Zhao², Chaoyi Feng¹, Mengwei Li¹, Yongheng Huang¹, Xinghuai Sun¹

Affiliations

¹ Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai 200031, China.
² Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China.

Abstract

We evaluate a cohort of optic neuritis and neuromyelitis optica (NMO) spectrum disorders patients in a territory hospital in China. The peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC) were measured using spectral-domain OCT after 6 months of acute onset. The results showed that both the peripapillary RNFL and macular GCC were significantly thinner in all optic neuritis subtypes compared to controls. In addition, the recurrent optic neuritis and NMO groups showed more severe damage on the RNFL and GCC pattern.