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. 2016 Feb 17;28(7):1472-6.
doi: 10.1002/adma.201504995. Epub 2015 Dec 9.

Combinatorial Biomolecular Nanopatterning for High-Throughput Screening of Stem-Cell Behavior

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Combinatorial Biomolecular Nanopatterning for High-Throughput Screening of Stem-Cell Behavior

Yacoub Y I Amin et al. Adv Mater. .

Abstract

A novel combinatorial biomolecular nanopatterning method is reported, in which multiple biomolecular ligands can be patterned in multiple nanoscale dimensions on a single surface. The applicability of the combinatorial platform toward cell-biology applications is demonstrated by screening the adhesion behavior of a population of human dental pulp stem cell (hDPSC) on 64 combinations of nanopatterned extracellular matrix (ECM) proteins in parallel.

Keywords: cell adhesion; combinatorial; high throughput; nanofabrication; protein patterning.

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