Investigation of the response variability of ionization chambers for the standard transfer of SIR-Spheres(®)

C Thiam; C Bobin; V Lourenço; V Chisté; M-N Amiot; X Mougeot; D Lacour; F Rigoulay; L Ferreux

doi:10.1016/j.apradiso.2015.11.056

Investigation of the response variability of ionization chambers for the standard transfer of SIR-Spheres(®)

Appl Radiat Isot. 2016 Mar:109:231-235. doi: 10.1016/j.apradiso.2015.11.056. Epub 2015 Nov 22.

Authors

C Thiam¹, C Bobin², V Lourenço², V Chisté², M-N Amiot², X Mougeot², D Lacour², F Rigoulay², L Ferreux²

Affiliations

¹ CEA, LIST, Laboratoire National Henri Becquerel (LNE-LNHB), Bât. 602, PC 111, 91191 Gif-sur-Yvette Cedex, France. Electronic address: cheick.thiam@cea.fr.
² CEA, LIST, Laboratoire National Henri Becquerel (LNE-LNHB), Bât. 602, PC 111, 91191 Gif-sur-Yvette Cedex, France.

PMID: 26651176
DOI: 10.1016/j.apradiso.2015.11.056

Abstract

The present paper addresses the calibration of well-type ionization chambers (ICs) used at LNE-LNHB as standard transfer instruments to calibrate hospitals in the case of SIR-Spheres(®)(90)Y resin microspheres (Sirtex, Australia). Developed for interventional oncology, this radiopharmaceutical is directly injected in the liver for cancer treatment via a selective internal radiation therapy. The present work was carried out in the framework of the European project "Metrology for molecular radiotherapy" (MetroMRT). As commonly performed in radionuclide metrology for radiopharmaceuticals, the objective is to ensure the metrological traceability of SIR-Spheres(®) to hospitals. Preceding studies were focused on primary measurements of SIR-Spheres(®) based on the TDCR (Triple to Double Coincidence Ratio) method, applied after the dissolution of the (90)Y-labeled resin microspheres. As (90)Y is a high-energy β(-)-emitter, the IC response strongly depends on the transport of electrons in the radioactive solution and surroundings (vial, chamber liners and materials). The variability of the IC-response due to the geometry dependence is investigated by means of measurements and Monte Carlo simulations in the case of a Vinten IC. The aim of the present study was also to propose a reliable uncertainty for ICs calibrations for the standard transfer of SIR-Spheres(®) to hospitals.

Keywords: (90)Y-labeled resin microspheres; Ionization chamber calibration; Monte Carlo simulation; Radionuclide metrology; SIR-Spheres(®) standardization.