Induction Therapy With a Combination of Fumarates and Cyclosporine: A Benefit for the Patient?

J Dermatolog Treat. 2016 Aug;27(4):381-2. doi: 10.3109/09546634.2015.1115817. Epub 2015 Dec 10.

Abstract

Fumarates or fumaric acid esters derivates (FAED) have appeared to be effective and less toxic than other systemic treatments for psoriasis. Due to its safe adverse event profile, FAED can be used as a long-term maintenance therapy. One of the greatest reasons why FAED are not preferred as a first-line treatment is that according to the recommended dosing schedule, clinically meaningful improvement is seen just after 6 to 8 weeks of therapy. In this manuscript, we suppose an alternative induction scheme with a combination therapy of fumarates and cyclosporine for a more rapid improvement and better compliance.

Keywords: Fumarates; combination; cyclosporine; fumaric acid esters derivates; psoriasis; therapy; treatment.

MeSH terms

  • Cyclosporine / administration & dosage*
  • Drug Therapy, Combination / methods*
  • Fumarates / administration & dosage*
  • Humans
  • Patient Compliance
  • Psoriasis / drug therapy*

Substances

  • Fumarates
  • Cyclosporine