Use of psychiatric medications in schizophrenia and other psychoses in a general population sample

Psychiatry Res. 2016 Jan 30;235:160-8. doi: 10.1016/j.psychres.2015.11.013. Epub 2015 Nov 10.

Abstract

The information on the use of psychiatric medications in general population-based samples is limited. Our aim was to analyse the use of psychiatric medications and factors associated with antipsychotic use in psychoses in a general population sample. Fifty-five persons with schizophrenia, 21 with bipolar psychosis or psychotic depression and 20 with other psychoses from the Northern Finland Birth Cohort 1966 were examined at about 43 years of age. The frequency of use and dosage of psychiatric medication and the factors associated with the use of antipsychotics were analysed. Antipsychotics were used by 85% of schizophrenia, 65% of bipolar psychosis or psychotic depression and 62% of other psychoses cases; antidepressants were used by 22%, 60% and 33%; and benzodiazepines by 42%, 35% and 10%, respectively. In all the diagnostic groups, higher symptom scores and a higher number of hospital days were associated with the use of antipsychotics. In schizophrenia and other psychoses, poorer social and occupational functioning, and in other psychoses, female gender and lower education were also associated with the use of antipsychotics. Our results may partly indicate that, especially in schizophrenia, the effectiveness of antipsychotics is not as good as expected.

Keywords: Antipsychotic; Follow-up; Medication; Predictor; Psychosis; Treatment.

MeSH terms

  • Adult
  • Antidepressive Agents / therapeutic use
  • Antipsychotic Agents / therapeutic use*
  • Benzodiazepines / therapeutic use
  • Bipolar Disorder / drug therapy
  • Cohort Studies
  • Depressive Disorder, Major / drug therapy
  • Educational Status
  • Female
  • Finland / epidemiology
  • Humans
  • Male
  • Psychotic Disorders / drug therapy*
  • Schizophrenia / drug therapy*
  • Sex Factors

Substances

  • Antidepressive Agents
  • Antipsychotic Agents
  • Benzodiazepines