Acute reduction in blood pressure following consumption of anthocyanin-rich cherry juice may be dose-interval dependant: a pilot cross-over study

Int J Food Sci Nutr. 2016;67(1):47-52. doi: 10.3109/09637486.2015.1121472. Epub 2015 Dec 13.

Abstract

A pilot cross-over study assessed the acute effects on blood pressure and plasma biomarkers associated with consumption of a 300 ml anthocyanin-rich fruit juice, provided in differing dose-intervals. Young adults (n = 6) and older adults (n = 7) received in random order, either a single 300 ml dose or 3 × 100 ml doses of high-flavonoid cherry juice provided at 0, 1 and 2 h. Blood pressure and plasma levels of phenolic metabolites were measured at 0, 2 and 6 h.The single 300 ml dose of cherry juice resulted in a significant reduction in systolic (p = 0.002), and diastolic blood pressure (p = 0.008) and heart-rate (p = 0.033) 2 h after consumption, before returning to baseline levels at 6 h post-consumption. The 3 × 100 ml dose provided over 2 h did not result in significant blood pressure reductions. Plasma phenolic metabolites increased at 2 and 6 h; however, fluctuations were higher after the single 300 ml dose in older adults. These findings have implications for design of intervention studies that investigate vascular effects associated with flavonoid-rich foods.

Keywords: Acute; anthocyanins; blood pressure; cherry juice; cross-over; dose.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anthocyanins / administration & dosage*
  • Anthocyanins / pharmacology
  • Biomarkers / blood
  • Blood Pressure / drug effects*
  • Cross-Over Studies
  • Flavonoids / pharmacology
  • Fruit / chemistry*
  • Fruit and Vegetable Juices*
  • Humans
  • Hypertension
  • Phenols / blood*
  • Pilot Projects
  • Plant Extracts / administration & dosage*
  • Plant Extracts / pharmacology
  • Prunus / chemistry*
  • Young Adult

Substances

  • Anthocyanins
  • Biomarkers
  • Flavonoids
  • Phenols
  • Plant Extracts